Translational Research: From Lab Bench to Clinical Application

The Pacific Ovarian Cancer Research Consortium (POCRC) consists of a group of dedicated and enthusiastic scientists from a variety of disciplines who have come together to address the issues that we view as most critical in controlling ovarian cancer. We have identified five areas where opportunities exist for us to make a difference.

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The first encompasses a randomized controlled trial (RCT) to compare safety, feasibility and positive predictive value (PPV) of two ovarian cancer screening strategies, one using CA125 and HE4 together as a first-line screen, the other introducing HE4 as a second-line screen. (Project 1).

The second involves the validation of a tool to increase the effectiveness of ultrasound for diagnosing ovarian cancer in its earliest stages when it is highly likely to be cured (Project 2).

The third involves the development and validation of a microRNA-based blood test to improve the predictive accuracy of clinical factors for identifying patients with poorly resectable ovarian cancer. (Project 3).

The fourth is to determine the clinical relevance of restoration of BRCA1/2 function in BRCA1/2-deficient ovarian carcinoma (Project 4).

The fifth is to evaluate the immunogenicity, therapeutic efficacy, and safety of an IGFBP-2 class II polyepitope plasmid DNA vaccine (Project 5).

To maintain a high level of interaction among scientists and to rapidly communicate novel discoveries throughout the group, the POCRC has four essential "Research Cores."

The Leadership Core acts as the foundation for scientific interaction, direction, mentoring, and program development.

The Clinical Core serves as the liaison with the community for all POCRC research studies, and is responsible for identification, enrollment and follow-up of all study participants.

The Specimen Core collects, manages, characterizes, and distributes tissue, blood and fluid products to support POCRC research projects.

The Informatics Core supports the ongoing statistical analyses and data management efforts of POCRC investigators and those who access repository specimens.